|
Wiskott-Aldrich Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subclass levels were normal in all but one (who was IgG3 deficient) patient with the Wiskott-Aldrich syndrome and in the Buckley's syndrome, except for an unusual patient who presented with low IgG and IgA levels.
|
2924438 |
1989 |
|
Warm autoimmune hemolytic anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We observed more wAIHA patients with high titer of IgG1 and high prevalence of IgG1+IgG3 and consider that patients without hemolysis having identical results might be interesting to find out how they are protected from damage by RBC autoAbs.
|
31708346 |
2020 |
|
Virus Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Deficiencies in immunoglobulin (Ig) G subclasses 1 (IgG1) and 3 (IgG3) and complement protein C4 are associated with susceptibility to and persistence of bacterial and viral infections.
|
19879913 |
2010 |
|
Virus Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
We aimed to evaluate patient factors including nonadherence and viral infection and de novo donor-specific antibody (dnDSA) characteristics [total immunoglobulin G (IgG), C1q, IgG3, and IgG4] as predictors of renal allograft failure in a multicenter cohort with dnDSA.
|
30597643 |
2019 |
|
Urinary tract infection
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Consistent with a lower affinity of the isoform encoded by the FCGR3A [158 F] to both IgG1 and IgG3, a significantly higher incidence of urinary tract infections (UTIs) was observed in the FCGR3A [158 F/V or F/F] individuals (65.5%) than in the FCGR3A [158 V/V] individuals (34.5%) following KT.
|
28315348 |
2017 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition to the expected upregulation of various cytokine and chemokine genes, novel immune function-related genes such as IGHG3, IGLL2 and CD74, inflammation-related lipocalins HNL and NGAL, and proliferation-related GRO genes were over-expressed in UC.
|
11181568 |
2001 |
|
Tuberculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In general, the TB group showed statistically higher levels of IgG1, and lower levels of IgG3.
|
29523330 |
2018 |
|
Trisomy 18 Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG3 subclass-positive primary thymic MALT lymphoma without trisomy 3 and trisomy 18: report of a case and review of literature.
|
25674276 |
2014 |
|
Transplant glomerulopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Complement binding IgG3 donor-specific antibodies are frequently associated with acute antibody-mediated rejection and severe graft injury, whereas noncomplement binding IgG4 donor-specific antibodies are more correlated with subclinical or chronic antibody-mediated rejection and transplant glomerulopathy.
|
28446536 |
2018 |
|
trachomatis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Chlamydia trachomatis elementary body enzyme-linked immunosorbent assay (ELISA) was used to investigate serum anti-CT immunoglobulin G1 (IgG1; long-lived response) and immunoglobulin G3 (IgG3; short-lived response indicating more recent infection) from treatment (enrollment) and 6-month follow-up visits in 77 women previously classified as having spontaneous resolution of chlamydia.
|
28444306 |
2017 |
|
Toxoplasmosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
334 subjects (124 BD, 75 SZ and 135 Healthy Controls [HC]) were included and tested for humoral immunity by determining the total immunoglobulins (IgG,A and M) and IgG subclasses (IgG1, IgG2, IgG3, IgG4) and their relationship with latent Toxoplasma gondii infection, an established risk factor for BD and SZ.
|
30053866 |
2018 |
|
Tonsillitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with recurrent tonsillitis had significantly lower mean of most assessed immunoglobulins: IgA (P = 0.002), IgM (P = 0.003), IgG (P < 0.0001), IgG1 (P < 0.0001) and IgG3 (P < 0.0001) compared to normal subjects; with no significant difference in mean of IgG2 (P = 0.395) and IgG4 (P = 0.105).
|
31445931 |
2020 |
|
Thrombocytopenia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Since anti-H/PF4 Abs are mainly IgG1 and IgG3, clearance of sensitized platelets may be increased in patients homozygous for the FcgammaRIIIa-158V allotype, thus contributing to the development of thrombocytopenia.
|
15191947 |
2004 |
|
Thalassemia
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, our main objective was to study the changes in MSP2-specific total IgG, IgG1 and IgG3 responses during a malaria transmission season in order to assess the impact of sickle-cell, α(+)-thalassemia and G6PD variants on antibody kinetics.
|
21549219 |
2011 |
|
Systemic candidiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Complement is essential for protection by an IgM and an IgG3 monoclonal antibody against experimental, hematogenously disseminated candidiasis.
|
11466376 |
2001 |
|
Strongyloidiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
When using MP treated antigen we observed reduction in IgG1 and IgG3 detection in strongyloidiasis group and decrease of cross reactions in control groups.
|
29454735 |
2018 |
|
Skin lesion
|
0.010 |
Biomarker
|
group |
BEFREE |
The mild clinical phenotype of BP230-type BP may correlate with the weaker deposition of IgG1, IgG3 and complement in the skin lesions.
|
30394605 |
2019 |
|
Sickle Cell-SS Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, our main objective was to study the changes in MSP2-specific total IgG, IgG1 and IgG3 responses during a malaria transmission season in order to assess the impact of sickle-cell, α(+)-thalassemia and G6PD variants on antibody kinetics.
|
21549219 |
2011 |
|
Sickle Cell Trait
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG3 and IgG2 were predominantly detected in plasma samples from HbAS children, whereas mainly IgG3 was found in children with HbAA.
|
12161278 |
2002 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protective efficacy of monoclonal antibodies (MAbs) 4C5 (IgG1) and 19A10 (IgG3) was demonstrated both in murine sepsis and pulmonary infection.
|
27795303 |
2017 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protective efficacy of monoclonal antibodies (MAbs) 4C5 (IgG1) and 19A10 (IgG3) was demonstrated both in murine sepsis and pulmonary infection.
|
27795303 |
2017 |
|
Schizophrenia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strikingly highest levels of antibodies to T. gondii (but not CMV) infection in BD and SZ were associated with lowest levels of IgG3 and IgG4 levels as compared to controls.
|
30053866 |
2018 |
|
Schistosomiasis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Since, IgG1 and IgG3 are involved in parasite killing and in protective immunity the findings reported here suggest the use of Sm29 as a potential candidate vaccine against schistosomiasis.
|
16734606 |
2006 |
|
Schistosomiasis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, in contrast to IgG3, increases in PM-specific IgE may contribute to suppression of liver pathogenesis in schistosomiasis.
|
17297052 |
2007 |
|
Schistosomiasis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Schistosoma mansoni tetraspanin 2 (Sm-TSP-2) has been shown to be strongly recognized by IgG1 and IgG3 antibodies from individuals putatively resistant to schistosome infection, but not chronically infected people, and to induce high levels of protection against challenge infection in the murine model of schistosomiasis.
|
21655308 |
2011 |